Roadmap
Where the map is going
A milestone trail for the CEF and RITE map. The foundation was built lean and self-funded. From here, support carries the map and the research path forward, milestone by milestone. This is a living document and it changes as the research does.
Educational computer modeling. For computational modeling and observational research only.
CEF
Cellular Expression Failure (CEF)
A modeled state where cells have lost precise control over expression and function.
RITE
RITE · the Sequence
Our name for the Sequence: the order-and-timing map the model runs against CEF profiles.
Roadmap
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Map math
- Done
- Self-funded
The math framed the order-and-timing question.
- Mechanism framed in the model
- Modelling process documented end to end, so runs can be reproduced
- Low-overhead infrastructure, built lean
- Independent researcher loop reviews model runs
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Educational models
- Done
- Ongoing
- Self-funded
Built educational models that ask how order and timing change the map.
- IP protected: patents pending and trade secret backed
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Published map
- Ongoing
Published the map as a hypothesis, not a protocol.
The map exists as math for researchers to test; it is not a proven clinical protocol.
-
Dual-world door
- In progress
Dual-world site door open (Home / How it works / In simple words / Founder / Insights / Pipeline).
-
Open notes
- Ongoing
Open observation notes on Substack.
-
Independent support
- Soft
Independent, mission-aligned support path (perks, not a raise story).
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Research-hardware path
- Soft
Research-hardware path to test the map.
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Researcher tools
- Soft
- In progress
Building tools that help researchers run the model.
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Hardware support
- Soft
Non-equity support for research hardware that maps the math.
Where support goes
Support funds the map, not a lifestyle
Every contribution goes into the work: the models, the tools, and the research path that tests the map. The foundation was self-funded, and we keep running lean so support reaches milestones, not overhead.
A personal experience is not proof. Soft support funds the map and the research path. Patents pending and trade secrets protect the work so it is not shelved for the richest buyout. The steps stay careful and public where they can teach.
- 01
Modelling runs
Compute and modelling runs that map CEF profiles against RITE, the Sequence.
- 02
Researcher tools
Tools that let independent researchers run, read, and check the model.
- 03
Research hardware
A research-hardware path to test the map, supported on a non-equity basis.
- 04
Open explainers
Free public explainers and open modelling notes, so the why stays clear.
Lean by design. No lavish offices, no pitch-tour budget. Milestones first.
Tracks
Where the work runs in parallel
- 01
Platform
Foundation and IP protection done, self-funded. Next: scale quantitative cell-line experiments to replicate, catalogue, and publish standard selectivity and response profiles across modelled cell states.
- 02
Hardware
Research-hardware path to test the map.
- 03
Software
Tools that help researchers run and read the model.
- 04
- 05
Model tracks
Model tracks the map explores next, each labelled as a hypothesis for researchers to test:
- Model track Vascular and micro-vascular kinetics
- Model track Recovery dynamics after acute stress loads
- Model track Pre-emptive clearance patterns in damaged tissue models
- Model track Senolytic-like selectivity patterns
Our milestones trace the path from foundational CEF biology toward predictive models that map precise expression control in CEF profiles. Each step is built to be checked, not just announced.
Sascha Biederbeck, Founder & CEO
What we say in public grows only as the research earns it.
Stay close to the work
Follow the open trail. New explainers and modelling notes land first on Substack. Stay close, then back the research media when the story earns it.
Patrons get early cuts of explainers and a name in the credits when we offer that. Your support funds the map, the research path, and the media around it.
We are building this to be used, not shelved. The work is dedicated to people first.
Independence keeps the maths unhurried.